Read the following exchange. I found it in a similiar search for my full blood chow:
My dog, 15 years old,a mixed chow, has cushing's ...
Sent to Dog Experts October 18 02:19 PM
My dog, 15 years old,a mixed chow, has cushing's disease. How can I get her not to drink so much water. She has stopped eating (this is day four) and today, 1st day, is on ANIPRYL 10mg per day.1. Will this help? 2. Is this enough medication.
She is Lethargic, Anorexia, Pants, generaly week and I'm sure depressed. I'm trying different foods she likes but she doesn't want them. I gave the Anipryl pills with liverwurst and her vitamins (liquid) with vanilla ice cream. I 'm afraid if she doesn't starting eating soon It might be to late to even help her. My vet says this is normal for her to drink water. she consuming about one full quart per day, it's so much water that she doesn't feel hungry. what else can I do??
Customer (name blocked for privacy)
Status: Closed Value: $9
Answer
October 18 3:21 PM (1 hour and 2 minutes and 13 seconds later)
ACCEPTEDCheck Mark
Hyperadrenocorticism (Cushing’s) is the result of overproduction of cortisol by the adrenal glands. This may be the result of a tumor on one of the adrenals ( uncommon), a tumor of the pituitary gland which causes release of hormones that signal the adrenal glands to produce cortisol (90% of cases), or iatrogenic (man-made, caused as the result of giving the dog steroid medications for too long a period of time or at too high a dosage). The disease is seen most commonly in middle-aged to older animals and certain breeds (Poodles, Beagles, Boston Terriers, Dachsunds) seem to have a higher breed predilection.
Cortisol has effects on every major organ system in the body. Generally, clinical signs include excessive drinking and urination, increased appetite, increased panting, lethargy, hair loss, weakness, and a pot belly that is a result of a combination between enlargement of the liver and a weakening of the muscles of the abdominal wall. These patients also tend to
develop darkening of the skin and comedones (black heads).
If the Cushing's is a result of an adrenal tumor (best determined via ultrasound exam), then surgical removal of the affected adrenal gland is the treatment of choice. Prognosis is generally good following surgery.
Treatment for pituitary tumors usually involves use of a drug called mitotane (Lysodren). This drug destroys the part of the adrenal glands responsible for making the excess cortisol; it does nothing for the pituitary tumor itself. Treatment can be hard on the patient and includes: lethargy, decreased appetite, vomiting, diarrhea, and ataxia (wobbly gait). It may also lead to the opposite of Cushing's, that is, it may cause very low levels of cortisol, which brings with it it's own very serious and potentially fatal consequences. So animals on this medication should be monitored very closely, especially in the initial loading phase (higher doses of drug given initially, then weaned to lowest effective dose).
Another treatment for Cushing's involves the use of a drug called selegiline hydrochloride (Anipryl). This helps to decrease the pituitary's signal to the adrenals by modifying levels of the hormone ACTH. It is generally much better tolerated than mitotane, but it must be given daily for the rest of the patient's life.
You did not give your dog's body weight, but the dose that she is receiving (10 mg) is appropriate for a 19 pound dog. I would expect a Chow mix to be larger than this, so she probably isn't getting enough medication. If she is around 19 pounds, then the dose is correct and it will just take you a few days to begin to see improvement. It is NOT normal for her to drink excessively, so if this doesn't begin to resolve on the medication then her dose will need to be altered (can go as high as 2 mg/kg/day) or she'll need to be switched to Lysodren.
Untreated/ uncontrolled Cushing's is ultimately fatal as it can lead to multiple organ dysfunction. The elevated cortisol levels alter the body's response to insulin, so these patient's can become diabetic. The animal will likely suffer kidney damage as a result of high blood pressure and loss of large sized proteins through the filtering mechanism of the kidney. They are at high risk of developing blood clots to the lungs; and they may develop neurologic signs if the tumor in the pituitary (which is located in the brain) becomes large.
I hope the information was helpful.
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RGK -- Veterinarian -- 100% Positive Feedback on 240 Dog Accepts
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Comments
I would agree. Check her teeth, watch to see if she has trouble making poo. Sounds like she is in pain. She needs to see a Vet, take a fresh stool sample.
by 60s Rock on October 23rd, 2007