Depends on context. You and I where I would be relevant, You and me where me would be relevant. You and I like toffee, but he likes you and me.

lolz i think both ways are right .. not too sure i've always used both.. sorry i couldn't help much :)have a lovely day lolz i googled this is what i got hope it helps "You and I" or "You and me"? Consider the following sentence: You and I should have lunch. Is the correct form of this sentence You and I ... or You and me ...? This is a common source of confusion in English. Fortunately, there's an easy way to decide whether to use I or me in such sentences. All you have to do is drop the word you then try the sentence with I and me one at a time. For example: * I should have lunch. * Me should have lunch. Clearly the preferred form in this case is I; thus, the original sentence was correct to use you and I. Here's another example: He'll blame you and I. Drop the word you then try the sentence with I and me one at a time, like so: * He'll blame I. * He'll blame me. You can see that the second of these is correct. This means that the original sentence should have been: He'll blame you and me. Easy. On a related note, when using phrases such as you and me, you and I or them and us, it has traditionally been considered courteous to place the reference to yourself last. For example, we prefer: * He'll ask you and me later. over: * He'll ask me and you later.

Use you and I as a subject and use you and me as an object.

Depends on who you are talking to. Being grammatically correct can sound pretentious and hinder communication, with some people.

i think You and Me sounds better. i'm actually working on a poem and i was tossing between the name You and Me or You and I and You and Me sounds better

depends on the usage. for instance: it's you and me, against the world you and i think the same