• Palmitoyl pentapeptide shows promise as a wrinkle reducing agent in skin rejuvenation products, but only further research on this compound can determine exactly how helpful it may prove and what dosages do the most good, according to


    Palmitoyl pentapeptide, also known as Matrixyl, contains a set of five amino acids combined with a fatty acid to resemble a natural precursor of collagen, an essential skin component.

    How It Works

    Palmitoyl pentapeptide stimulates the production of new skin cells, helping to reduce wrinkles caused by collagen breakdown, though notes that the scientific community has yet to determine the precise mechanism behind this process.

    Clinical Results

    Palmitoyl pentapeptide could reduce facial wrinkles, according to the study Palmitoyl-Pentapeptide: Retinol-like Efficacy with Less Irritation by Karl Lintner, Ph.D., Larry R. Robinson, Ph.D., and Donald L. Bissett, Ph.D. points out, however, that Proctor & Gamble sponsored the study and is also manufacturer of the compound, implying a possible conflict of interest.


    Matrixyl, the trademarked name for palmitoyl pentapeptide, appears in the ingredients lists of several commercial skin care products. notes that this "classic" version differs from an unrelated skin care product called Matrixyl 3000.


    While palmitoyl pentapeptide may help skin remain healthy, the varying concentrations of this compound in skin care products, coupled with incomplete scientific data, make it more of an extra option than an essential skin care aid.

    Source: Palmitoyl pentapeptide-4 (Matrixyl), a gentler wrinkle cure candidate

    Palmitoyl-Pentapeptide: Retinol-like Efficacy with Less Irritation. Karl Lintner, Ph.D.; Larry R. Robinson, Ph.D.; & Donald L. Bissett, Ph.D.

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