There are things we can change and things we can not change and there is wisdom in knowing the difference. I'll give you that wisdom. The things we can not change is everything outside of us, what people do, how people react, situations, events, and the long slow processes of time. Can't change them. The things we CAN change are those things inside of us, how we "accept" the behaviors of others, how we react to the actions of other, how we adjust to the passage of time. Your anger and resentment is not going to change your sisters. I doubt even rational sit down discussion will pull them away from their "busy" lives. The hard part will be to swallow that anger and resentment and "accept" them for who they are and the situations this causes. You can 'buy' yourself time by hiring a helper part time to give you a break to allow you to have "me time". One of the things you really need to do is seek professional therapy. There is a very large amount of stress being a caregiver for a loved one. Society knows this and there are sessions that are specifically designed to help you the caregiver to deal with not only the anger and the resentment you have of your siblings, but the anger and resentment you will have or do have toward your mother, the guilt that those feelings bring about and the anxiety that you are somehow "bad" for being angry. If any of this sounds familiar to you its because anybody in your situation has these sorts of feelings. This are normal actions/reactions that come with the territory. If you do not feel these toward your mother, its most likely due to channeling all of that pent up angst at the "able" targets - your sisters. So if the anger feels "too much" for their behaviors, then most likely its because you are angry about a lot of things - not specifically them, they just make a good target a good "reason". Again we are dealing with "normal" expected behaviors. Ones that can be dealt with and should be dealt with with a professional therapist. You are ok, given your situation your feelings are valid, and you are "correct" in feeling the way you do. Further, as a care giver you should seriously speak to your mom's doctor and ask him/her if there are any helpful programs that will 1. Help you mom 2. Give you more "space" and "me time" to recharge. Many states have visiting nurses (state paid) visiting maids (state paid) and other programs designed to help families with people who need care.