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How long does it take for anti-anxiety medication (Clonazepam) to take effect? I have been on Clonazepam for a little over a month. I take 0.5mg twice daily. Once in the morning and once in the evening. You have to take medications like this daily at around the same time each day. I felt the calming affects within 5 minutes of taking my first dose and there on after. It works quicker if you do not swallow it. Just let it sit on your tongue and dissolve. It does not have a...

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