• Like most drugs, the effect is much stronger on an empty stomach. Also, methadone doesn't really cause nausea, so don't take it with food (even though the bottle/doctor might tell you to).
  • any narcotic works faster and better on an empty stomache but be careful cuz it can cause a stomache ache. its like if you were to drink on an empty stomache, it kicks in faster
  • if i havent eaten all day and i take it i get really agitated and annoyed like i dont feel right but if i eat first then take it i feel great!

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