by 
mishie
ANSWERS: 3
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Presuming you mean historically? I guess one of our ancestors chewed a leaf one day and discovered it had a benificial effect on him and it just went from there!
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Most naturally occurring drugs are essentially poisons which plants generate inside themselves in order to protect themselves from being eaten by insects. What is lethal in large quantities to an insect can be entertaining in small quantities to a human. However, you have to remember that they were originally designed to kill.
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From plants, and there were used in ancient countries like: Egypt, Peru, India, China and Persia
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