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by Mayed_87 on February 13th, 2008

Mayed_87

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Do you have G6PD? and how do you deal with it?

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Answers. 4 helpful answers below.

  • by iwnit on February 14th, 2008

    iwnit

    I assume you mean G6PD *deficiency*? I hope not, but maybe it could stay undiagnosed in some cases?

    "Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (most notably erythrocytes) by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage.

    G6PD converts glucose-6-phosphate into 6-phosphoglucono-δ-lactone and is the rate-limiting enzyme of the pentose phosphate pathway."

    "Glucose-6-phosphate dehydrogenase deficiency is very common worldwide, and cause acute hemolytic anemia in the presence of simple infection, ingestion of fava beans, or reaction with certain medicines, AAA, antibiotics, antipyretics, and antimalarials."
    Source and further information:
    http://en.wikipedia.org/wiki/G6PD


    2) "Patients are almost exclusively male, due to the X-linked pattern of inheritance, but female carriers can be clinically affected due to lyonization where random inactivation of an X-chromosome in certain cells creates a population of G6PD deficient red cells coexisting with normal red cells. G6PD manifests itself in a number of ways:

    Prolonged neonatal jaundice
    Hemolytic crises in response to:
    Certain drugs (see below)
    Certain foods, most notably broad beans
    Illness (severe infections)
    Diabetic ketoacidosis
    Very severe crises can cause acute renal failure
    Favism is a disorder characterized by hemolytic anemia in response to ingestion of fava beans."

    "The diagnosis is generally suspected when patients from certain ethnic groups (see below) develop anemia, jaundice and symptoms of hemolysis after challenge to any of the above causes, especially when there is a positive family history."
    Source and further information:
    http://en.wikipedia.org/wiki/Glucose-6-phosphate_dehydrogenase_deficiency


    3) do you have it and how do you deal with it?

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  • by Penny_W1670 on March 10th, 2012

    Penny_W1670

    Well I'm Just lo oking into it because I want to rty NAC I really didn't know how serious it was I came down with chronic urniary infections Itt not diagnose Mar-2010-till Aug tumor blockerage hopitalized with on the brink of renal failure....So I guess I need to a Hematogist??? I had serveral viral infections and a couple of blood transfusions now still wearing bilateralnephrosis tubes goin for test see if they can be removed soon

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  • by valentina21459@msn.com on June 14th, 2010

    valentina21459@msn.com

    Share your answer...

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  • by valentina21459@msn.com on June 14th, 2010

    valentina21459@msn.com

    I have g6pd and I learn what is contraindicated regarding medications and foods. I wear a medic alert bracelet, I take NAC amino acids to aid my body in making g6pd. I take note every day of the color of my urine, my skin, to determine if I am in hemolysis. I see a hematologist and I go directly to the hospital if I suspect I am in hemolysis (dying red blood cells). I do not eat processed foods, asthey contain soy mos of the time and I avoid all food dyes, as they are petroleum based.

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