Here's the top 50 as of April 20, 2006 HOUSTON ASTROS CAREER WINS W 1 Joe Niekro 144 2 Larry Dierker 137 3 Mike Scott 110 4 J.R. Richard 107 5 Nolan Ryan 106 6 Don Wilson 104 7 Shane Reynolds 103 8 Bob Knepper 93 9 Roy Oswalt 86 10 Ken Forsch 78 11 Darryl Kile 71 12 Mike Hampton 69 13 Jim Deshaies 61 14 Wade Miller 58 T15 Dave Smith 53 T15 Turk Farrell 53 17 Mark Portugal 52 T18 Dave Giusti 47 T18 Danny Darwin 47 T18 Dave Roberts 47 21 Jose Lima 46 T22 Pete Harnisch 45 T22 Tom Griffin 45 24 Joaquin Andujar 44 T25 Bob Bruce 42 T25 Jim Ray 42 27 Vern Ruhle 39 28 Doug Drabek 38 29 Mike Cuellar 37 30 Joe Sambito 33 T31 Ken Johnson 32 T31 Scott Elarton 32 33 Roger Clemens 31 T34 Greg Swindell 30 T34 Denny Lemaster 30 36 Jack Billingham 29 37 Billy Wagner 26 38 Jerry Reuss 25 T39 Juan Agosto 24 T39 Don Sutton 24 T39 Andy Pettitte 24 T42 Fred Gladding 22 T42 Bill Dawley 22 T42 Octavio Dotel 22 T42 Larry Andersen 22 T42 Xavier Hernandez 22 T47 Tim Redding 21 T47 Chris Holt 21 T47 Don Nottebart 21 T47 Mark Lemongello 21 T47 Hal Woodeshick 21