by 
Anonymous
ANSWERS: 2
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http://www.slate.com/id/2152255 tells some of the biggest.
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According to Craig Rowland, Scrabble in North America recognizes five words which, if spelled over two triple-word score squares, and with a premium-scoring tile on the double-letter score square, will award the player 392 points on a single play. These five words are: OXAZEPAM, BEZIQUES, CAZIQUES, MEZQUITS, and MEZQUITE. John Chew says that OXYPHENBUTAZONE is the highest-scoring word known under American tournament Scrabble rules (OSPD+MWCD). It can score 1778 under suitably contrived circumstances listed and credited in the Scrabble FAQ. The highest-scoring opening plays are MUZJIKS (128) in OSPD and QUARTZY (126) or SQUEEZY (126) in OSW. Bruce D. Wilner says if we include eight-letter "bingos" that use all seven letters on one's rack plus a letter already on the board, then WHIZBANG, QUETZALS, and HIGHJACK score an incredible 374 points for a single play if the highest-point tile is on a light blue square and both the first and last letters are on red squares. QUIXOTIC and MUSQUASH are right behind, scoring 356 and 338, respectively. Source: http://www.funtrivia.com/askft/Question46398.html
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