• The secondary immune system uses antibodies.
  • Primary immune responses involve immune and humoral responses. Primary can be complement-mediated, often involving a large immune protein (immunoglobulin) called type M, or IgM. These react initially when some form of immune recognition is made of the foreign agent. These complement-IgM complexes are "presented" to a type of white blood cell called B cells. These B cells take the foreign agent that is presented to them and absorbs it. It then creates a line of IgB, immnunoglobulin type G, a much smaller immune protein, in huge quantities. These IgG make up the secondary response. So, when the body encounters the foreign agent a second time, the IgG stand ready to react. This is called sensitization, and with each exposure, the body creates more IgG in defense. This defense is the secondary response.

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