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Cholestasis is a rare condition that involves a reduction of bile flow from the liver to the small intestine. When bile flow is hindered, a waste product pigment called bilirubin can escape into the bloodstream and build up to harmful levels. This may lead to the symptoms of jaundice, itching, and impaired growth and eventually to more serious health problems. Four rare genetic liver disorders are— AGS, a-1AT, bile acid synthesis and metabolism defects and PFIC .
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