See a doctor.

In sensitive individuals, Cayenne may cause severe allergic reactions and inflammation of the eyes, nose, and gums. On the skin, full-strength capsaicin can cause inflammation, blisters, and ulcers, and even mild medicinal preparations should be handled with care. You did not go by the right measurements, which is only 1/10 a tsp per drink.I would seek medical advise. For those naysayers, go to www.therawfoodsite.com to find out about the master cleanse that has been around since 1979 and not a "new" fad.

I realize this question is about a month old, but for anyone who stumbles across it... I'm not sure why you received blisters unless, as mentioned earlier, you are sensitive to the cayenne and got it on your hands. I'm curious to know though if you experience this while handling cayenne while not on the cleanse. Seek your answer there. NOTE: The Master Cleanse has been around since the 1940's and if you do enough research, you'll find that the ingredients are safe and beneficial beyond anything that just water can do. Highly recommend this non-diet "fad".

yoho, as I did more research I did change my original post so that you would be better informed. Maybe you should have included exactly how much cayenne you did put in, so we all would have a better idea how to help you, since you asked for advise.

I found this on Ask.com, It really works! Blister Care If you get a blister, you'll want to relieve your pain, keep the blister from enlarging, and stave off infection. Specific steps depend on the size of the blister and whether or not it is intact. You can treat the vast majority of blisters yourself and need to call a doctor only if blisters become infected, recur frequently, form in unusual locations, or are very severe. Signs of infection include pus draining from the blister, very red or warm skin around the blister, and red streaks leading away from the blister. Small, intact blisters that don't cause discomfort usually need no treatment. Nature's best protection against infection is a blister's own skin, or roof. To protect the roof, this type of blister can be covered with a small adhesive bandage if practical. Larger or painful blisters that are intact should be drained without removing the roof. First clean the blister with rubbing alcohol or antibiotic soap and water. Then heat a straight pin or safety pin over a flame until the pin glows red, and allow it to cool before puncturing a small hole at the edge of the blister. Drain the fluid with gentle pressure, then apply an antibiotic ointment such as bacitracin with polymyxin B (double antibiotic ointment) or bacitracin alone. Avoid ointments that contain neomycin because they are more likely to cause an allergic reaction. Finally, cover the blister with a bandage. Change the dressing daily—more frequently if it becomes wet, soiled, or loose. Blisters with small tears are treated the same as those that you have punctured. Blisters with larger tears should be "unroofed" carefully with fine scissors, and the base should be cleansed thoroughly with soap and water or an antibacterial cleanser. Apply antibiotic ointment and bandages as described above. Additional padding may be necessary for exercise or sports. Ring-shaped pads made of felt will protect small blisters. Larger blisters may require dressings. Some of the many available dressing materials are DuoDerm (ConvaTec, Princeton, New Jersey), Spenco 2nd Skin (Spenco Medical Corporation, Waco, Texas), Vigilon (CR Bard Inc, Murray Hill, New Jersey), and Opsite (Smith & Nephew United, Largo, Florida). Additional, doughnutshaped padding made of felt or lamb's wool may be applied over the area surrounding the blister. Then the entire dressing can be applied to help keep the dressing in place on sweaty skin. Steps for Comfort The best way to avoid discomfor and time off from physical activities is to avoid blisters with some of the steps mentioned earlier. But if blisters do surface, prompt treatment will get you back to form quickly and help prevent infection. Remember: This information is not intended as a substitute for medical treatment. If you have serious health concerns, consult a physician.