No,someone always come up or ask another one.

Just when we think we know everything, we don't!..:)

I don't know, but more importantly: Have all the big questions already been answered?

I don't think there are big questions here, only lots of little ones about little things and big things. Other than "why are we here", everything else seems small.

1) As long as gameshow will exist, no. ;-) 2) "The biggest questions ever asked": "What is reality? By Roger Penrose Can we be sure that the world we experience is not just a figment of our imaginations? What is life? By Robert Hazen If we encountered alien life, chances are we wouldn't recognise it - not even if it were here on Earth Do we have free will? By Patricia Churchland The more we find out about how the brain works, the less room there seems to be for personal choice or responsibility Is the universe deterministic? By Vlatko Vedral However you look at it, the answer seems to be "maybe" What is consciousness? By Paul Broks How does the brain, with its diverse distributed functions, come to arrive at a unified sense of identity? Will we ever have a theory of everything? By Michio Kaku 2000 years of rational enquiry may be approaching their crowning glory. Just one more push could be enough What happens after you die? By Mary Roach We have all wondered if there is an afterlife, but only a few are brave - or foolish - enough to try and find out What comes after humans? By James Hughes All species are fated either to die out or to evolve into something else - all except humans, who have a chance of a transcendent future" Source and further information: http://www.newscientist.com/article/mg19225780.068-the-biggest-questions-ever-asked.html 3) Have those questions already been asked on AB? What is reality? http://www.answerbag.com/q_view/94815 Similar questions: http://www.answerbag.com/q_view/474938 http://www.answerbag.com/q_view/292866 http://www.answerbag.com/q_view/318770 http://www.answerbag.com/q_view/134007 What is life all about? (What is life?) http://www.answerbag.com/q_view/605686 Do we really have free will? (Do we have free will?) http://www.answerbag.com/q_view/522162 Similar questions: http://www.answerbag.com/q_view/117169 http://www.answerbag.com/q_view/118830 http://www.answerbag.com/q_view/386226 Do we live in a deterministic universe? Explain your answer. (Is the universe deterministic?) http://www.answerbag.com/q_view/441388 What is consciousness? http://www.answerbag.com/q_view/97046 Similar questions: http://www.answerbag.com/q_view/306048 http://www.answerbag.com/q_view/305959 Will we ever have a theory of everything? http://www.answerbag.com/q_view/613399 (I did not find it asked, so I just asked it...) What do you believe happens after we die? (What happens after we die?) http://www.answerbag.com/q_view/551515 Similar questions: http://www.answerbag.com/q_view/266507 http://www.answerbag.com/q_view/436527 http://www.answerbag.com/q_view/116062 http://www.answerbag.com/q_view/283271 http://www.answerbag.com/q_view/388907 http://www.answerbag.com/q_view/397879 What comes after humans? http://www.answerbag.com/q_view/613411 (I did not find it asked, so I just asked it...) 4) Personally, I think that the more answers we find, the more questions we usually have, and some of them are quite big ones!