Reggie Jackson with 2,597 Here's a list of all the players with at least 1500 strikeouts: STRIKEOUTS SO 1 Reggie Jackson 2597 2 Sammy Sosa 2194 3 Andres Galarraga 2003 4 Jose Canseco 1942 5 Willie Stargell 1936 6 Mike Schmidt 1883 7 Fred McGriff 1882 8 Tony Perez 1867 9 Dave Kingman 1816 10 Jim Thome 1765 11 Bobby Bonds 1757 12 Dale Murphy 1748 13 Lou Brock 1730 14 Mickey Mantle 1710 15 Harmon Killebrew 1699 16 Chili Davis 1698 17 Dwight Evans 1697 18 Rickey Henderson 1694 19 Dave Winfield 1686 20 Gary Gaetti 1602 21 Mark McGwire 1596 22 Lee May 1570 23 Craig Biggio 1560 24 Jeff Bagwell 1558 25 Dick Allen 1556 T26 Ray Lankford 1550 T26 Willie McCovey 1550 28 Dave Parker 1537 29 Frank Robinson 1532 30 Lance Parrish 1527 T31 Willie Mays 1526 T31 Devon White 1526 33 Reggie Sanders 1521 34 Eddie Murray 1516 T35 Rick Monday 1513 T35 Greg Vaughn 1513 37 Andre Dawson 1509