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Both Zyrtec-D and Allegra-D contain the decongestant pseudoephedrine, while Zyrtec-D contains the antihistamine cetirizine and Allegra-D contains the anithistamine fexofenadine. They both work in the same way to alleviate allergy symptoms. According to Drugs.com, Zyrtec-D and Allegra-D have similar side effects including dizziness, drowsiness, uneven heartbeat, dry mouth, problems with vision, and increased blood pressure. However, Allegra-D does have a slightly longer list of side effects, including hallucinations and skin rash.
While side effects are similar, Allegra-D has several more possible negative drug interactions than Zyrtec-D. According to Drugs.com, Allegra-D has been known to negatively interact with certain over-the-counter drugs like aspirin and water pills.
As the list of side effects and possible negative drug interactions are both more extensive for Allegra-D, Zyrtec-D seems a better choice for over-the-counter allergy relief. However, it is necessary to speak with a physician to make the best choice for your health.
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