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Estrogen supplements such as Premarin increase the levels of the hormone estrogen in the body, which aids in symptoms of early menopause, and helps prevent bone loss in women. The supplements also carry risks, as they have been found to contribute to increased breast cancer risk in the long term. Estrogen supplementation has been shown to reduce the loss of bone associated with early menopause. In addition, the supplements have been shown to have the effect of working to improve the density of bones. Other changes which occur with supplementation include elevation of skin collagen, improvement in mood disorders related to estrogen loss, and increased vaginal lubrication. Estrogen also helps to minimize hot flashes. Estrogen supplements are associated with increased clotting of the blood. This has the detrimental effect of increasing the risk of strokes, deep vein thrombosis (a form of blood clotting in the legs) and pulmonary embolisms (clotting in the lungs). A study known as the Million Women Study of English women between 50 and 64 years old found that taking any kind of estrogen supplementation for over 10 years increased the women's risk of breast cancer. Estrogen supplements cause the lining of the uterine wall to build up. This can lead to uterine cancer, which can be avoided by taking progestin with the estrogen. Women above 65 may be at greater risk of dementia if they are taking estrogen.Benefits
Clotting
Breast Cancer
Uterine changes
Neurological changes
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