by 
The Curious Bag
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Whipple's disease is a rare, potentially deadly bacterial infection most commonly affecting the small intestine.
Cause
The infection is caused by the Tropheryma whipplei, a bacteria that is relatively common outside of the human body. Many people carry the bacteria without showing signs of symptoms, which has led researchers to believe that some people are genetically predisposed to the infection.
Symptoms
Symptoms include abdominal pain, anemia, chronic diarrhea, fatigue, fever and joint pain. Less common symptoms include respiratory problems, skin darkening and heart problems. The infection can also affect the brain, eyes, lungs and joints.
Diagnosis
Once other conditions are ruled out, doctors examine the small intestine with an endoscope and collect tissue samples for biopsy. DNA or electron microscopy analysis can confirm the presence of Tropheryma whipplei.
Treatment
The standard treatment involves the administration of IV antibiotics for several weeks, followed by a one- to two-year course of oral antibiotics. While the disease is fatal if untreated, the chances of complete recovery are good and symptoms typically vanish within a month.
Expert Insight
Middle-aged Caucasian men are most commonly affected by Whipple's disease.
Source:
National Digestive Diseases Information Clearinghouse: Whipple's Disease
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