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The Curious Bag
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Non-hodgkin's lymphoma (NHL) affects lymphocytes, the white blood cells that play important roles in immunity. While the medical community has not pinpointed the exact cause of this cancer, several things appear to influence its development.
Cell Cycle
Normally, your lymphocytes die at a certain time and are replaced by new ones. NHL occurs when abnormal cells do not die, but continue to grow and divide. Excess cells lead to swollen lymph nodes, according to the Mayo Clinic.
DNA
DNA changes called translocations can trigger NHL, according to the American Cancer Society. Translocation occurs when DNA from one chromosome separates and joins with another chromosome. This process can interfere with genes that suppress tumor growth.
Chronic Infection
People with chronic infections continually produce new lymphocytes to fight their illness. This increased production increases the risk of creating abnormal lymphocytes that can lead to NHL.
Compromised Immunity
Anything that interferes with normal immune function can lead to NHL. Organ transplants and other conditions that suppress immunity as well as autoimmune diseases can damage lymphocytes.
Chemicals
Certain chemicals, like those to kill weeds and insects, might contribute to NHL, according to the Mayo Clinic.
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