1) "Sumatriptan (trade names Imitrex, Imigran, Imigran recovery) is a triptan drug including a sulfonamide group for the treatment of migraine headaches. It is marketed and manufactured by GlaxoSmithKline." "Large doses of sumatriptan (200 mg/day) can cause sulfhemoglobinemia, a rare condition in which the blood changes from red to greenish-black, due to the integration of sulfur into the hemoglobin molecule[4]. If sumatriptan is discontinued, the condition reverses within a few weeks. Serious cardiac events, including some that have been fatal, have occurred following the use of Imitrex Injection or Tablets. Events reported have included coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia, and ventricular fibrillation. In the below table, "Common" is reported in at least 1/100 patients, "Less common" in 1/100 to 1/1000 patients and "Rare" in less than 1/1000 patients[5]. Type Common Less Common Rare Atypical Sensations Burning sensations and numbness "tight feeling around the head" Dysesthesia Cardiovascular Palpitations, syncope, as well as changes in blood pressure. Arrhythmia, changes in ECG, hypertension, hypotension, pallor, pulsating sensations, and tachycardia. Angina, atherosclerosis, bradycardia, cerebral ischemia, cerebrovascular lesion, heart block, peripheral cyanosis, thrombosis, transient myocardial ischemia, and vasodilation. Ear, Nose, and Throat Sinusitis, tinnitus; allergic rhinitis; upper respiratory inflammation; ear, nose, and throat hemorrhage; external otitis; hearing loss; nasal inflammation; and sensitivity to noise. Hearing disturbances and otalgia. Feeling of fullness in the ear(s). Endocrine and Metabolic Thirst. Elevated thyrotropin stimulating hormone (TSH) levels; galactorrhea; hyperglycemia; hypoglycemia; hypothyroidism; polydipsia; weight gain; weight loss; endocrine cysts, lumps, and masses; and fluid disturbances. Eye Sclera, mydriasis, blindness and low vision, visual disturbances, eye edema and swelling, eye irritation and itching, accommodation disorders, external ocular muscle disorders, eye hemorrhage, eye pain, and keratitis and conjunctivitis. Gastrointestinal Diarrhea and gastric symptoms. Constipation, dysphagia, and gastroesophageal reflux. Gastrointestinal bleeding, hematemesis, melena, peptic ulcer, gastrointestinal pain, dyspeptic symptoms, dental pain, feelings of gastrointestinal pressure, gastritis, gastroenteritis, hypersalivation, abdominal distention, oral itching and irritation, salivary gland swelling, and swallowing disorders. Hematological Disorders Anemia Musculoskeletal Myalgia Muscle cramps. Tetany; muscle atrophy, weakness, and tiredness; arthralgia and articular rheumatitis; acquired musculoskeletal deformity; muscle stiffness, tightness, and rigidity; and musculoskeletal inflammation. Neurological Phonophobia and photophobia. Confusion, depression, difficulty concentrating, disturbance of smell, dysarthria, euphoria, facial pain, heat sensitivity, incoordination, lacrimation, monoplegia, sleep disturbance, shivering, syncope, and tremor. Aggressiveness, apathy, bradylogia, cluster headache, convulsions, decreased appetite, drug abuse, dystonic reaction, facial paralysis, hallucinations, hunger, hyperesthesia, hysteria, increased alertness, memory disturbance, neuralgia, paralysis, personality change, phobia, radiculopathy, rigidity, suicide, twitching, agitation, anxiety, depressive disorders, detachment, motor dysfunction, neurotic disorders, psychomotor disorders, taste disturbances, and raised intracranial pressure. Respiratory Dyspnea. Asthma. Hiccoughs, breathing disorders, cough, and bronchitis. Skin Sweating. Erythema, pruritus, rash, and skin tenderness. Dry/scaly skin, tightness of skin, wrinkling of skin, eczema, seborrheic dermatitis, and skin nodules. Breasts Tenderness. Nipple discharge, swelling, cysts, lumps, masses and primary malignant breast neoplasm. Urogenital Dysmenorrhea, increased urination, and intermenstrual bleeding. Abortion and hematuria, urinary frequency, bladder inflammation, micturition disorders, urethritis, urinary infections, menstruation symptoms, abnormal menstrual cycle, inflammation of fallopian tubes, and menstrual cycle symptoms. Miscellaneous Hypersensitivity. Fever, fluid retention, and overdose. Edema, hematoma, lymphadenopathy, speech disturbance, voice disturbances, contusions." Source and further information: http://en.wikipedia.org/wiki/Imitrex (I suggest you look at the original for a table view) 2) "Most important fact about Imitrex Imitrex should be used only to treat an acute, classic migraine attack or a cluster headache. It should not be used for certain unusual types of migraine. How should you take Imitrex? Imitrex should be taken as soon as your symptoms appear, but may be used at any time during an attack. It is available in three forms: injection, tablets, and nasal spray." "Imitrex Oral Side Effects Flushing, sensations of tingling/numbness/prickling/heat, weakness, drowsiness, or dizziness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Chest/jaw/neck tightness can commonly occur shortly after using sumatriptan. Only rarely are these signs of a serious condition. However, you may not be able to tell it apart from a serious reaction related to a lack of blood flow to the heart, brain or other parts of the body. Seek immediate medical attention if any of these unlikely but very serious (rarely fatal) side effects occur: chest pain jaw/left arm pain fainting fast/irregular/pounding heartbeat vision changes weakness on one side of the body confusion slurred speech sudden or severe stomach/abdominal pain bloody diarrhea Tell your doctor immediately if any of these unlikely but serious side effects occur: blue fingers/toes/nails cold sensation of hands/feet hearing changes mental/mood changes seizures This medication may rarely cause a very serious condition called serotonin syndrome. The risk increases when this medication is taken with certain other drugs such as other "triptans" used to treat migraine headaches (e.g., rizatriptan, zolmitriptan), certain antidepressants including SSRIs (e.g., citalopram, fluoxetine, paroxetine) and NSRIs (e.g., duloxetine, venlafaxine), or a certain drug to treat obesity (sibutramine). Before taking this drug, tell your doctor if you take any of these medications. Serotonin syndrome may be more likely when you start or increase the dose of any of these medications. Seek immediate medical attention if you develop some of the following symptoms: hallucinations unusual restlessness loss of coordination fast heartbeat severe dizziness high fever severe nausea/vomiting/diarrhea twitchy muscles" Source and further information: http://www.healthcentral.com/migraine/find-drug-126911-73.html Further information: http://www.drugs.com/imitrex.html http://www.rxlist.com/imitrex-drug.htm http://www.webmd.com/drugs/drug-11571-Imitrex+Oral.aspx http://www.healthcentral.com/migraine/find-drug-1069-150.html