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An increased ESR rate may be due to: * Anemia * Kidney disease * Osteomyelitis * Pregnancy * Rheumatic fever * Rheumatoid arthritis * Syphilis * Systemic lupus erythematosus * Thyroid disease * Tuberculosis * Other inflammatory conditions Very high ESR levels occur with: * Giant cell arteritis * Hyperfibrinogenemia (increased fibrinogen levels in the blood) * Multiple myeloma * Macroglobulinemia - primary * Necrotizing vasculitis * Polymyalgia rheumatica Take a look at this web site it might answer a few of your queries about it:- http://www.nlm.nih.gov/medlineplus/ency/article/003638.htm
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