Here's a list up to and including the 2005 season: NATIONAL LEAGUE SEASON RUNS YEAR R 1 Billy Hamilton 1894 192 (some sources have 198) 2 Billy Hamilton 1895 166 T3 Joe Kelley 1894 165 T3 Willie Keeler 1894 165 5 Willie Keeler 1895 162 T6 Jesse Burkett 1896 160 T6 Hugh Duffy 1894 160 8 Hughie Jennings 1895 159 T9 Bobby Lowe 1894 158 T9 Chuck Klein 1930 158 T11 John McGraw 1894 156 T11 Rogers Hornsby 1929 156 T13 Kiki Cuyler 1930 155 T13 King Kelly 1886 155 T15 Jesse Burkett 1895 153 T15 Dan Brouthers 1887 153 T15 Willie Keeler 1896 153 T18 Lefty O'Doul 1929 152 T18 Chuck Klein 1932 152 T18 Jeff Bagwell 2000 152 T18 Woody English 1930 152 T18 Billy Hamilton 1897 152 T18 Billy Hamilton 1896 152 24 George Gore 1886 150 T25 Herman Long 1893 149 T25 Bill Dahlen 1894 149 T25 Ed Delahanty 1895 149 T28 Jake Stenzel 1894 148 T28 Hub Collins 1890 148 T28 Joe Kelley 1895 148 T28 Joe Kelley 1896 148 T32 Mike Tiernan 1889 147 T32 Ed Delahanty 1894 147 T32 Hugh Duffy 1893 147 T35 Sammy Sosa 2001 146 T35 Hack Wilson 1930 146 T35 Craig Biggio 1997 146 T38 Patsy Donovan 1894 145 T38 Cupid Childs 1893 145 T38 Jesse Burkett 1893 145 T38 Ed Delahanty 1893 145 T38 Willie Keeler 1897 145 T43 Kiki Cuyler 1925 144 T43 Hugh Duffy 1889 144 T45 John McGraw 1898 143 T45 Larry Walker 1997 143 T45 Cupid Childs 1894 143 T45 Jeff Bagwell 1999 143 T45 Lenny Dykstra 1993 143 T45 Babe Herman 1930 143 T51 Paul Waner 1928 142 T51 Jesse Burkett 1901 142 T51 Ellis Burks 1996 142 T54 Billy Hamilton 1891 141 T54 Rogers Hornsby 1922 141 T56 John McGraw 1899 140 T56 Jimmy Ryan 1889 140 T56 Max Carey 1922 140 T56 Mike Griffin 1895 140 T56 Willie Keeler 1899 140 T61 Bill Terry 1930 139 T61 Dan Brouthers 1886 139 T63 Mel Ott 1929 138 T63 Jesse Burkett 1894 138 T63 Todd Helton 2000 138 T66 Johnny Mize 1947 137 T66 Roy Thomas 1899 137 T66 Albert Pujols 2003 137 T66 Billy Williams 1970 137 T66 Bill Dahlen 1896 137 T66 Ginger Beaumont 1903 137 T66 Dan Brouthers 1894 137 T73 Herman Long 1894 136 T73 George Van Haltren 1896 136 T73 Cupid Childs 1892 136 T73 Mike Griffin 1897 136 T77 Stan Musial 1948 135 T77 Jack Rowe 1887 135 T77 Hack Wilson 1929 135 T77 Tom Daly 1894 135 T77 Ed Delahanty 1899 135 T77 Todd Helton 2003 135 T77 Hughie Jennings 1898 135 T84 Sammy Sosa 1998 134 T84 Frank Robinson 1962 134 T84 Lloyd Waner 1929 134 T84 Walt Wilmot 1894 134 T84 Bobby Bonds 1970 134 T84 Steve Brodie 1894 134 T84 Cliff Carroll 1890 134 T84 Fielder Jones 1897 134 T84 Hughie Jennings 1894 134 T93 Albert Pujols 2004 133 T93 Lloyd Waner 1927 133 T93 Tim Raines 1983 133 T93 Billy Hamilton 1890 133 T93 Augie Galan 1935 133 T93 Rogers Hornsby 1927 133 T93 Rogers Hornsby 1925 133 T93 Hughie Jennings 1897 133 T101 Billy Nash 1894 132 T101 Joe Medwick 1935 132 T101 Duke Snider 1953 132 T101 Pee Wee Reese 1949 132 T101 Jimmy Ryan 1894 132 T101 Roy Thomas 1900 132 T101 Mike Tiernan 1890 132 T101 Mike Tiernan 1896 132 T101 Jay Bell 1999 132 T101 Todd Helton 2001 132 T101 Billy Hamilton 1892 132 T101 George Gore 1889 132