Here's a list up to and including the 2005 season: AMERICAN LEAGUE SEASON RUNS YEAR R 1 Babe Ruth 1921 177 2 Lou Gehrig 1936 167 T3 Babe Ruth 1928 163 T3 Lou Gehrig 1931 163 T5 Babe Ruth 1920 158 T5 Babe Ruth 1927 158 7 Al Simmons 1930 152 T8 Babe Ruth 1923 151 T8 Joe DiMaggio 1937 151 T8 Jimmie Foxx 1932 151 T11 Babe Ruth 1930 150 T11 Ted Williams 1949 150 T13 Babe Ruth 1931 149 T13 Lou Gehrig 1927 149 15 Ty Cobb 1911 147 16 Rickey Henderson 1985 146 T17 Harlond Clift 1936 145 T17 Nap Lajoie 1901 145 T19 Al Simmons 1932 144 T19 Ty Cobb 1915 144 T19 Charlie Gehringer 1936 144 T19 Charlie Gehringer 1930 144 T19 Hank Greenberg 1938 144 T24 Red Rolfe 1937 143 T24 Babe Ruth 1924 143 T24 Earle Combs 1932 143 T24 Lou Gehrig 1930 143 28 Ted Williams 1946 142 T29 Alex Rodriguez 1996 141 T29 Ted Williams 1942 141 T31 Earl Averill 1931 140 T31 Chuck Knoblauch 1996 140 T33 Red Rolfe 1939 139 T33 Babe Ruth 1926 139 T33 Jimmie Foxx 1938 139 T33 Lou Gehrig 1928 139 T37 Roberto Alomar 1999 138 T37 Tommy Henrich 1948 138 T37 Lou Gehrig 1932 138 T37 Lou Gehrig 1933 138 T37 Lou Gehrig 1937 138 T42 Tris Speaker 1920 137 T42 George Sisler 1920 137 T42 Eddie Collins 1912 137 T42 Frankie Crosetti 1936 137 T42 Earle Combs 1927 137 T42 Hank Greenberg 1937 137 T48 Tris Speaker 1912 136 T48 Paul Molitor 1982 136 T48 Earl Averill 1936 136 T48 Johnny Damon 2000 136 T52 Johnny Mostil 1925 135 T52 Ted Williams 1941 135 T52 Lou Gehrig 1926 135 T55 Alex Rodriguez 2000 134 T55 George Sisler 1922 134 T55 Ted Williams 1940 134 T55 Derek Jeter 1999 134 T55 Shawn Green 1999 134 T55 Charlie Gehringer 1934 134 T61 Tris Speaker 1923 133 T61 Paul Molitor 1991 133 T61 Alex Rodriguez 2001 133 T61 Willie Wilson 1980 133 T61 Charlie Gehringer 1938 133 T61 Charlie Gehringer 1937 133 T67 Jack Tobin 1921 132 T67 Red Rolfe 1938 132 T67 Joe DiMaggio 1936 132 T67 Roberto Alomar 1996 132 T67 Mickey Mantle 1956 132 T67 Kenny Lofton 1996 132 T67 Mickey Mantle 1961 132 T67 Roger Maris 1961 132 T75 Manny Ramirez 1999 131 T75 Ted Williams 1939 131 T75 Lu Blue 1922 131 T75 Dom DiMaggio 1950 131 T75 Charlie Gehringer 1929 131 T80 Jimmie Foxx 1936 130 T80 Jimmie Foxx 1939 130 T80 Rickey Henderson 1986 130 T80 Charlie Jamieson 1923 130 T84 Bill Werber 1934 129 T84 Robin Yount 1982 129 T84 Earle Combs 1930 129 T84 Rocky Colavito 1961 129 T84 Joe DiMaggio 1938 129 T84 Mickey Mantle 1954 129 T84 Hank Greenberg 1940 129 T91 Alfonso Soriano 2002 128 T91 Roger Peckinpaugh 1921 128 T91 Ken Williams 1922 128 T91 Rod Carew 1977 128 T91 Earl Averill 1934 128 T91 Wade Boggs 1988 128 T91 Eddie Joost 1949 128 T91 Roy Johnson 1929 128 T91 Lou Gehrig 1934 128 T100 Ichiro Suzuki 2001 127 T100 Frankie Crosetti 1937 127 T100 Dom DiMaggio 1948 127 T100 Jimmie Foxx 1930 127 T100 Joe Cronin 1930 127 T100 Derek Jeter 1998 127 T100 Mickey Mantle 1958 127 T100 Lou Gehrig 1929 127 T108 Zoilo Versalles 1965 126 T108 Ray Durham 1998 126 T108 Donie Bush 1911 126 T108 Dom DiMaggio 1949 126 T108 Joe Jackson 1911 126 T108 Ron LeFlore 1978 126 T108 Odell Hale 1936 126