Here's a list up to and including the 2005 season: SEASON RUNS YEAR R 1 Billy Hamilton 1894 192 (some sources have 198) T2 Babe Ruth 1921 177 T2 Tom Brown 1891 177 T4 Lou Gehrig 1936 167 T4 Tip O'Neill 1887 167 6 Billy Hamilton 1895 166 T7 Joe Kelley 1894 165 T7 Willie Keeler 1894 165 T9 Lou Gehrig 1931 163 T9 Arlie Latham 1887 163 T9 Babe Ruth 1928 163 12 Willie Keeler 1895 162 13 Hugh Duffy 1890 161 T14 Jesse Burkett 1896 160 T14 Fred Dunlap 1884 160 T14 Hugh Duffy 1894 160 17 Hughie Jennings 1895 159 T18 Chuck Klein 1930 158 T18 Bobby Lowe 1894 158 T18 Babe Ruth 1920 158 T18 Babe Ruth 1927 158 T22 Rogers Hornsby 1929 156 T22 John McGraw 1894 156 T24 King Kelly 1886 155 T24 Kiki Cuyler 1930 155 T26 Willie Keeler 1896 153 T26 Jesse Burkett 1895 153 T26 Dan Brouthers 1887 153 T29 Mike Griffin 1889 152 T29 Billy Hamilton 1896 152 T29 Billy Hamilton 1897 152 T29 Arlie Latham 1886 152 T29 Chuck Klein 1932 152 T29 Lefty O'Doul 1929 152 T29 Jeff Bagwell 2000 152 T29 Woody English 1930 152 T29 Harry Stovey 1889 152 T29 Al Simmons 1930 152 T39 Jimmie Foxx 1932 151 T39 Babe Ruth 1923 151 T39 Joe DiMaggio 1937 151 T42 Ted Williams 1949 150 T42 George Gore 1886 150 T42 Babe Ruth 1930 150 T45 Lou Gehrig 1927 149 T45 Herman Long 1893 149 T45 Babe Ruth 1931 149 T45 Bill Dahlen 1894 149 T45 Ed Delahanty 1895 149 T50 Joe Kelley 1895 148 T50 Joe Kelley 1896 148 T50 Hub Collins 1890 148 T50 Jake Stenzel 1894 148 T54 Ed Delahanty 1894 147 T54 Ty Cobb 1911 147 T54 Hugh Duffy 1893 147 T54 Mike Tiernan 1889 147 T58 Hack Wilson 1930 146 T58 Rickey Henderson 1985 146 T58 Darby O'Brien 1889 146 T58 Craig Biggio 1997 146 T58 Tom Brown 1890 146 T58 Sammy Sosa 2001 146 T64 Nap Lajoie 1901 145 T64 Willie Keeler 1897 145 T64 Jesse Burkett 1893 145 T64 Cupid Childs 1893 145 T64 Harlond Clift 1936 145 T64 Ed Delahanty 1893 145 T64 Patsy Donovan 1894 145 T71 Charlie Gehringer 1930 144 T71 Charlie Gehringer 1936 144 T71 Billy Hamilton 1889 144 T71 Hank Greenberg 1938 144 T71 Kiki Cuyler 1925 144 T71 Hugh Duffy 1889 144 T71 Ty Cobb 1915 144 T71 Al Simmons 1932 144 T79 Larry Walker 1997 143 T79 Lou Gehrig 1930 143 T79 Babe Herman 1930 143 T79 John McGraw 1898 143 T79 Red Rolfe 1937 143 T79 Babe Ruth 1924 143 T79 Jeff Bagwell 1999 143 T79 Cupid Childs 1894 143 T79 Lenny Dykstra 1993 143 T79 Earle Combs 1932 143 T89 Paul Waner 1928 142 T89 Ted Williams 1946 142 T89 Mike Griffin 1887 142 T89 Ellis Burks 1996 142 T89 Jesse Burkett 1901 142 T89 Harry Stovey 1890 142 T95 Ted Williams 1942 141 T95 Billy Hamilton 1891 141 T95 Rogers Hornsby 1922 141 T95 Alex Rodriguez 1996 141 T99 Mike Griffin 1895 140 T99 Willie Keeler 1899 140 T99 Chuck Knoblauch 1996 140 T99 Jim McTamany 1890 140 T99 John McGraw 1899 140 T99 Tom Poorman 1887 140 T99 Jimmy Ryan 1889 140 T99 Earl Averill 1931 140 T99 Max Carey 1922 140 T108 Lou Gehrig 1928 139 T108 Jimmie Foxx 1938 139 T108 Bid McPhee 1886 139 T108 Red Rolfe 1939 139 T108 Babe Ruth 1926 139 T108 Dan Brouthers 1886 139 T108 Charles Comiskey 1887 139 T108 Hub Collins 1889 139 T108 Bill Terry 1930 139