Here's the top 50 as of April 20, 2006 HOUSTON ASTROS CAREER STRIKEOUTS SO 1 Nolan Ryan 1866 2 J.R. Richard 1493 3 Larry Dierker 1487 4 Mike Scott 1318 5 Shane Reynolds 1309 6 Don Wilson 1283 7 Joe Niekro 1178 8 Darryl Kile 973 9 Bob Knepper 946 10 Roy Oswalt 866 11 Ken Forsch 815 12 Jim Deshaies 731 T13 Billy Wagner 694 T13 Turk Farrell 694 15 Mike Hampton 693 16 Wade Miller 659 17 Tom Griffin 652 18 Dave Giusti 625 19 Bob Bruce 609 20 Jose Lima 584 21 Pete Harnisch 583 22 Doug Drabek 558 23 Mike Cuellar 557 24 Octavio Dotel 552 25 Danny Darwin 543 26 Mark Portugal 535 27 Dave Smith 529 28 Ken Johnson 471 29 Denny Lemaster 450 30 Joe Sambito 421 T31 Dave Roberts 403 T31 Roger Clemens 403 33 Joaquin Andujar 388 34 Scott Elarton 384 T35 Brad Lidge 381 T35 Jim Ray 381 37 Xavier Hernandez 354 38 Jerry Reuss 351 T39 Larry Andersen 346 T39 Chris Holt 346 41 Jack Billingham 344 42 Vern Ruhle 313 43 Greg Swindell 309 44 Tim Redding 290 45 Don Nottebart 285 46 Andy Pettitte 268 47 Wade Blasingame 258 48 Hal Woodeshick 256 49 Don Sutton 243 50 Frank DiPino 233