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ESR is increased in rheumatoid diseases, most infections, and in cancer. An advanced rate doesn't diagnose a specific disease, but it does indicate that an underlying disease may be present.
A physician can use ESR to monitor a person with an associated disease. When the disease worsens, the ESR increases; when the disease improves, the ESR decreases. The ESR doesn't always follow the course of cancer.
ESR is called an acute-phase reactant test, meaning that it reacts to acute conditions in the body, such as infection or trauma. The rate increase follows a rise in temperature and white blood cells count, peaks after several days, and usually lasts longer than the elevated temperature or white blood cells count.
Source: The Gale Group. Gale Encyclopedia of Medicine, 3rd ed.";

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