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Histamines cause hives, which are itchy, red, raised bumps on skin, according to MedicineNet.com. Histamines cause many allergic reactions, and many rashes are the result of "allergic skin," according to MedicineNet.com.
Some skin problems are not caused by histamines. Coming into contact with poison ivy or poison oak can lead to an allergic reaction on skin. Fungus is another cause of skin conditions, such as ringworm, and bacteria can cause skin infections, including impetigo.
"Rash" is a general term for a variety of skin conditions. Some of these conditions, such as hives, are the result of histamines. The best treatment for a reaction is to identify and remove its trigger, which is not always possible. A doctor usually prescribes antihistamines to treat the condition.
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