by 
The Curious Bag
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Opiates are drugs derived from the opium poppy. While they affect everyone differently, feelings of euphoria, improved mood and relaxation are possible side effects of opiates. Overall, opiates are not considered a viable treatment for depression due to the high risk of overdose, addiction and serious adverse effects.
Pharmacology
Endorphins are naturally occurring chemicals in the body that produce feelings of relaxation, euphoria and general well-being. Opioid molecules fit into endorphin receptors in the brain, mimicking their effects and producing feelings perceived as extremely pleasant by some people.
Psychological Effects
Euphoria is a possible side effect of most opiate medications. According to a study by Andrew L. Stoll, M.D. and Stephanie Rueter, B.A., published in the American Journal of Psychiatry, opiates like oxycodone and oxymorphone can cause significant, sustained improvement in some patients with treatment-resistant depression.
Adverse Effects
Despite their potentially positive effects, opiates are not regularly prescribed to treat psychological conditions like depression. Overdose, addiction, withdrawal and increased tolerance to the positive effects of opiates are among the associated risks, making them poor candidates for treating depression.
Withdrawal and Depression
Opiate withdrawal can be particularly difficult for people with clinical depression. According to Health Central, psychological symptoms including increased anxiety, depression, agitation and cravings for the drug can occur upon cessation, all of which can be harmful in those with underlying mental illness.
Considerations
Using opiates for purposes inconsistent with their labeling increases the risks for serious adverse effects. If you suffer from symptoms of depression, talk to your doctor about your treatment options.
Source:
Health Central: Opiate Withdrawal
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