Nexium is the brand name for the proton pump inhibitor drug esomeprazole magnesium, which is used to treat gastroesophageal reflux disease (GERD) and reduce the risk of certain ulcers. Some Nexium side effects occur in both children (ages 1 to 17) and adults, while other adverse effects are unique to only one of these populations.

Major Side Effect

When AstraZeneca compared data from four separate clinical studies of Nexium, the company found that headache was the most commonly-reported side effect of the drug.

Common Side Effects

In addition to headaches, AstraZeneca reports that 1 percent or more of both adults and children taking Nexium experience diarrhea, abdominal pain, and nausea. Adults may also have flatulence (gas), constipation and dry mouth. Children may develop somnolence (drowsiness), but adults typically do not.

Less Common Side Effects

AstraZeneca also reports other less common side effects possibly or probably related to Nexium. These effects impact virtually every body system, with the esophagus, stomach and intestines being particularly hard hit.

Liver Damage

In the prescribing information for Nexium, AstraZeneca notes that the drug can interfere with liver function, and people with severe liver impairment should stick to a dose of 20 mg a day.

Masking of Stomach Cancer

Nexium may mask the symptoms of stomach cancer. Neil S. Dhillon, writing for the Consumer Health Information Corporation, warns against taking the drug for longer than directed on the bottle's label.

Source:

AstraZeneca: Nexium Full Prescribing Information

Consumer Health Information Corporation: Are You Taking Medications That Could Mask Your Symptoms?

More Information:

RX List: Nexium