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The first statin, Mevacor, was approved by the FDA in 1987 after the drug company Merck isolated a substance called lovastatin in 1979. Lovastatin was derived from a fungus called Aspergillus terreus.
Modern statins come from the fermentation of bacteria or are synthetically manufactured. There is no evidence that one version has a more beneficial effect than the other.
One exception is the statin pravastatin. This statin is derived from another statin (compactin) that comes from red rice yeast. Compactin had too many side effects, so it was pulled off the market.
There are also preservatives in statins that help the body process the drug more easily, and also act as coloration. These ingredients can include citric acid, iron oxides and starch.
Statins help people with high cholesterol by slowing down the enzyme HMG-CoA reductase. This enzyme is responsible for the production of cholesterol.
University of Michigan Business School: Case 10: Merck(A): Mevacor
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