A healthy air-conditioned room temperature will depend on several personal factors. Body fat, age, medications taken and metabolism can all affect your tolerance to higher or lower temperatures over a long period of time. Lean people will tolerate heat better than someone with more body fat. Younger people tolerate temperature extremes more easily than the elderly. Asthma and hay fever medications, among others, can affect your perception of heat and cold. If you have a higher metabolic rate, you'll tend to feel warmer than someone with a lower metabolic rate. Keep your air conditioning temperature set at a point where you do not feel overly cold or warm. It's healthier if your body isn't having to work to keep your temperature regulated. Another factor to keep in mind when choosing a healthy temperature is the relative humidity of the air. Dry air at 72 degrees F. will feel cooler than humid air at the same temperature.

On the Other: Avoid Shocking Temperature Changes

Particularly in the summer, it is healthier to keep your air conditioning set at around 10 degrees cooler than the temperature outside. You will be better able to adjust to the heat when spending time outdoors and your body will have to do less work to regulate your temperature when you leave or return to your house.

Bottom Line

Keep your air conditioning set where it is comfortable for you, not too hot or too cold. Except in extreme temperatures, try to keep this level within 10 degrees of the temperature outdoors to allow your body to stay acclimated.

Source:

University of Iowa Health Care: Acclimatization: Adjusting to the Temperature

Winter Indoor Comfort and Relative Humidity