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The statin drug Zocor lowers cholesterol by preventing the liver from making cholesterol.
Function
Zocor, which is also known by its generic name, simvastin, blocks the production of an enzyme called HMG-CoA reductase, which is necessary for the production of cholesterol in the liver.
Effects
When HMG-CoA is blocked, liver cells increase the production of proteins called LDL receptors, which pull cholesterol-carrying LDL particles out of circulation. In doing so, Zocor lowers blood levels of LDL cholesterol. In a clinical trial published in "The Lancet" in 1994, the drug lowered LDL cholesterol levels by 35 percent in heart disease subjects compared to a placebo.
Benefits
By lowering blood levels of LDL cholesterol, Zocor prevents plaque from forming in artery walls. This prevents heart attacks and other cardiovascular events.
Side effects
Zocor can cause side effects including muscle and joint pain.
Prescriptions
The U.S. patent for Zocor, which was owned by Merck & Co., expired in 2006. It is now available in its generic form, simvastin, as a prescription.
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