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  • Peyronie's disease leads to an abnormal bend in the penis, especially during an erection. This painful condition can cause distress as well as trouble having sexual intercourse, according to the Mayo Clinic.

    Underlying Cause

    The underlying cause of Peyronie's disease is unknown, but the best theory is that the bend in the penis caused by the condition begins with unusual development of fibrous tissue, according to MedlinePlus.

    Injury

    The Mayo Clinic says Peyronie's disease can develop after an injury to the penis during sports or sex.

    Features

    The fibrous tissue found in Peyronie's disease, reports the Mayo Clinic, occurs because of improper wound repair in the elastic tissue of the penis called the tunica albuginea.

    Co-Factor

    MedlinePlus reports a slight association between Peyronie's disease and Dupuytren's contracture, which causes thickening of the palms of the hands.

    Genetics

    MedlinePlus says it appears that men may inherit Peyronie's disease, as sufferers "have a certain type of immune cell marker."

    Source:

    Mayo Clinic: Peyronie's Disease Definition

    Mayo Clinic: Peyronie's Disease Causes

    Medline Plus: Peyronie's Diseasec

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