• Despite its effectiveness at alleviating pain and inflammation, napoxene poses a risk for side effects in some patients.

    Types of Side Effects

    Common side effects of napoxene include heartburn, abdominal pain, nausea, constipation, headache, dizziness, drowsiness, itching, rashes, ringing in your ears, swelling of your extremities and shortness of breath.

    Time Frame

    The most common side effects of napoxene usually develop when you first begin taking the drug and gradually diminish as your body becomes acclimated to the effects of the drug, explains the Mayo Clinic.

    Drug Interactions

    Combining napoxene with the mood-stabilizing drug lithium poses a risk for toxicity from the psychiatric medication. Patients who take both napoxene and the blood-thinning medication warfarin are at an increased risk for sudden gastrointestinal hemorrhages, reports the U.S. National Library of Medicine.


    In some patients, napoxene leads to ulceration of the digestive system, causing bleeding and even the formation of perforations. Additionally, there is a risk of life-threatening cardiovascular problems associated with long-term use of non-steroidal anti-inflammatory medications like napoxene, such as heart attacks and stroke, warns the U.S. National Library of Medicine.


    Because its effects upon fetal development are unknown, doctors rarely recommend napoxene for use in pregnant women. If you have a history of anemia, bleeding problems, blood clots, heart attacks or disease, hypertension, kidney or liver disease, stomach ulcers, stroke or aspirin-sensitivity, it may not be safe for you to take napoxene.


    U.S. National Library of Medicine

    Mayo Clinic

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