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Hyperthyroidism is not a known side effect of Advantage flea control for cats. Because Advantage is topical rather than ingested, it's unlikely that this medication would cause the enlarged thyroid responsible for feline hyperthyroidism.
Source:
PetEducation.com: The Use of Advantage in Dogs and Cats
EntirelyPets.com: Feline Hyperthyroidism
1800PetMeds.com: Advantage Flea Killer
More Information:
Advantage.PetParents.com: How to Apply Advantage Flea Control for Cats
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