ANSWERS: 1
  • For five years, Vioxx was marketed as an alternative to general anti-inflammatory medications because it caused less serious intestinal bleeding. However, the company that produced Vioxx removed it from the market because of potentially dangerous cardiovascular side effects.

    Vioxx Chemistry

    The chemical name of Vioxx is rofecoxib, a non-steroidal anti-inflammatory drug (NSAID). Merck & Co. marketed Vioxx between 1999 and 2004.

    Method of Action

    Vioxx is a COX-2 selective NSAID, specifically inhibiting cyclooxygenase-2. By contrast, non-selective NSAID medications such as aspirin target both cyclooxygenase-1 and cyclooxygenase-2.

    Vioxx Uses

    According to the Food and Drug Administration, Vioxx was approved in 1999 for the treatment of osteoarthritis and acute pain. Vioxx was believed to be a step above current NSAID medications because it didn't cause as many instances of ulcers and gastrointestinal bleeding.

    Side Effects

    Merck's VIGOR study uncovered an increased risk for cardiovascular illness, such as heart attacks, strokes, and blood clots, in patients who were administered Vioxx for more than 18 months.

    Current Market Situation

    In 2004, Merck voluntarily withdrew Vioxx from the U.S. drug market due to the risk of cardiovascular side effects seen among chronic users of the drug.

    Source:

    Drugs.com: Vioxx Overview

    Food and Drug Administration: Vioxx Information

    3DChem.com: Vioxx Chemistry

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