History

V. Craig Jordan, PhD, began researching what is now called Tamoxifen in the 1960s. He was responsible for uncovering the link between blocking estrogen receptors and lowering the incidence of breast cancer, according to Cancer.org.

Significance

According to the National Cancer Institute, tamoxifen is used to treat patients in the early stages of breast cancer or metastic breast cancer that has spread to other parts of the body. This drug can reduce the recurrence of breast cancer as well as prevent the spread of the cancer to the other breast if it has not already occured.

Function

Estrogen can increase the rate of breast cancer cell growth, according to the National Cancer Institute. By blocking the estrogen receptors, tamoxifen can reverse this impact by preventing the bonding of estrogen to cells thereby allowing cancer cells to thrive.

Indications

Tamoxifen can be prescribed for varying lengths of time according to the treatment plan the patient and doctor have created. According to the National Cancer Institute, the typical length is five years but studies have yet to identify a precise length of treatment.

Side Effects

Possible serious side effects include blood clots, strokes, uterine cancer and cataracts, according to the National Cancer Institute. MIlder side effects include hot flashes, vaginal discharge, irregular menstrual periods and vaginal dryness. Common side effects include headaches, fatigue, nausea, vomiting, rash and irritation of the skin.

Source

Tamoxifen Q&A

The Scientist Behind Tamoxifen