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If it takes you somewhere around 600mg-800mg of caffeine to feel appreciable effects, and even more throughout the span of the day..

If it takes you somewhere around 600mg-800mg of caffeine to feel appreciable effects, and even more throughout the span of the day(not from building a tolerance), is it plausible to suggest that your neurochemistry will resultantly tolerate and suffer less long-term negative consequences from megadose consumption of the substance?

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800mg of caffeine