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Women who take birth control pills--especially in low doses--potentially face a greater risk of becoming pregnant if they take penicillin at the same time because the penicillin sometimes lessens the potency of the birth control, according to Drugs.com. The Mayo Clinic reports that this generally occurs in only a small percentage of women and is disclosed as a precaution to all patients taking birth control pills.
Penicillin, a prescription antibiotic, has not undergone any large clinical studies that prove it reduces the effectiveness of birth control pills. Drugs.com and the Mayo Clinic report a potential for increased risk of pregnancy, but there is limited information on how penicillin affects birth control pills.
It's wise to use a secondary form of birth control such as a condom if you're taking penicillin.
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